Welcome to the Sadagurski Lab

 Exploring Brain–Body Communication in Metabolic Health and Aging 

Our lab studies how the brain, especially the hypothalamus, regulates metabolism in response to environmental stress, obesity, and aging. We focus on the interactions between neurons and glial cells (astrocytes and microglia) that influence energy balance and metabolic function. 

Using genetic, molecular, and metabolic tools in rodent models, we investigate how environmental exposures and age-related changes in the brain contribute to systemic metabolic disease. Our goal is to uncover new pathways and targets for improving metabolic health and resilience across the lifespan.