Sadagurski Lab

Neuroinflammation | Metabolism | Environmental Stressors & Aging

Projects


Neuroinflammation/Metabolism/Aging




The Role of Hypothalamic Neuroinflammation in the Aging Brain


The role of neuroinflammatory signals in the aging brain, with a major focus on age-dependent changes in hypothalamic inflammation and metabolic regulation.




Exposure to Air Pollution is a Trigger for Hypothalamic Inflammation and Metabolic Disease


Defining the mechanisms by which air pollution affects metabolic imbalance and identifying molecular mediators with specific emphasis on hypothalamic neuroinflammatory pathways that may ultimately have implications for potential interventions.




The Effect of Perinatal Exposure to VOC on Hypothalamic Development, Neuroinflammation, and Whole-body Metabolism in the Offspring


Using innovative technical approaches to assess the impact of perinatal VOC exposure on offspring hypothalamic development and inflammatory response in the hypothalamus, as a potential risk factor for late-life metabolic disorders




Hypothalamic Neuroendocrine Axis in Aging and Metabolism


Utilizing unique mouse models to analyze a novel population of hypothalamic neurons that are critical for the feedback inhibition of GH production in controlling systemic glucose homeostasis and regulating aging processes.

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