APA
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Snyder, J. M., Casey, K. M., Galecki, A., Harrison, D. E., Jayarathne, H., Kumar, N., … Ladiges, W. (2023). Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice. GeroScience, 45, 385–397. https://doi.org/10.1007/s11357-022-00641-0
Chicago/Turabian
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Snyder, Jessica M., Kerriann M. Casey, Andrzej Galecki, David E. Harrison, Hashan Jayarathne, Navasuja Kumar, Francesca Macchiarini, et al. “Canagliflozin Retards Age-Related Lesions in Heart, Kidney, Liver, and Adrenal Gland in Genetically Heterogenous Male Mice.” GeroScience 45 (February 2023): 385–397.
MLA
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Snyder, Jessica M., et al. “Canagliflozin Retards Age-Related Lesions in Heart, Kidney, Liver, and Adrenal Gland in Genetically Heterogenous Male Mice.” GeroScience, vol. 45, Feb. 2023, pp. 385–97, doi:10.1007/s11357-022-00641-0.
BibTeX Click to copy
@article{snyder2023a,
title = {Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice},
year = {2023},
month = feb,
journal = {GeroScience},
pages = {385--397},
volume = {45},
doi = {10.1007/s11357-022-00641-0},
author = {Snyder, Jessica M. and Casey, Kerriann M. and Galecki, Andrzej and Harrison, David E. and Jayarathne, Hashan and Kumar, Navasuja and Macchiarini, Francesca and Rosenthal, Nadia and Sadagurski, Marianna and Salmon, Adam B. and Strong, Randy and Miller, Richard A. and Ladiges, Warren},
month_numeric = {2}
}
Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% increase in the 90th percentile age when given to genetically heterogeneous male mice from 7 months of age, but does not increase lifespan in female mice. A histopathological study was conducted on 22-month-old mice to see if Cana retarded diverse forms of age-dependent pathology. This agent was found to diminish incidence or severity, in male mice only, of cardiomyopathy, glomerulonephropathy, arteriosclerosis, hepatic microvesicular cytoplasmic vacuolation (lipidosis), and adrenal cortical neoplasms. Protection against atrophy of the exocrine pancreas was seen in both males and females. Thus, the extension of lifespan in Cana-treated male mice, which is likely to reflect host- or tumor-mediated delay in lethal neoplasms, is accompanied by parallel retardation of lesions, in multiple tissues, that seldom if ever lead to death in these mice. Canagliflozin thus can be considered a drug that acts to slow the aging process and should be evaluated for potential protective effects against many other late-life conditions.