APA
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Sadagurski, M., Debarba, L., Werneck-de-Castro, J., Awada, A. A., Baker, T. A., & Bernal-Mizrachi, E. (2019). Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to diet rich in high fat and branched chain amino acids. American Journal of Physiology. Endocrinology and Metabolism.
Chicago/Turabian
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Sadagurski, M., L. Debarba, J. Werneck-de-Castro, Abear Ali Awada, Tess A. Baker, and E. Bernal-Mizrachi. “Sexual Dimorphism in Hypothalamic Inflammation in the Offspring of Dams Exposed to Diet Rich in High Fat and Branched Chain Amino Acids.” American Journal of Physiology. Endocrinology and Metabolism (2019).
MLA
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Sadagurski, M., et al. “Sexual Dimorphism in Hypothalamic Inflammation in the Offspring of Dams Exposed to Diet Rich in High Fat and Branched Chain Amino Acids.” American Journal of Physiology. Endocrinology and Metabolism, 2019.
BibTeX Click to copy
@article{m2019a,
title = {Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to diet rich in high fat and branched chain amino acids.},
year = {2019},
journal = {American Journal of Physiology. Endocrinology and Metabolism},
author = {Sadagurski, M. and Debarba, L. and Werneck-de-Castro, J. and Awada, Abear Ali and Baker, Tess A. and Bernal-Mizrachi, E.}
}
Branched-chain amino acid (BCAAs; leucine, isoleucine, and valine) contribute to the development of obesity-associated insulin resistance in the context of a high-fat diet (HFD) consumption in humans and rodents. Maternal diet is a major determinant of offspring health and there is strong evidence that maternal HFD alters hypothalamic developmental programming and disrupts offspring energy homeostasis in rodents. In this study, we exposed pregnant and lactating C57BL/6JB female mice to either HFD, HFD with supplemented BCAA (HFD+BCAA), or standard chow (SC) diets, and studied offspring metabolic phenotypes. Both maternal HFD and HFD supplemented with BCAA had similar effect rendered the offspring metabolic imbalance and impaired their ability to cope with HFD when challenged during aging. The metabolic effects of HFD challenge were more profound in females, worsening female offspring ability to cope with an HFD challenge by activating hypothalamic inflammation in aging. Moreover, the sex differences in hypothalamic ER-α expression levels were lost in female offspring upon HFD challenge, supporting a link between ER-α levels and hypothalamic inflammation in offspring and highlighting the programming potential of hypothalamic inflammatory responses and maternal nutrition.