Journal article
M. Sadagurski, L. Norquay, J. Farhang, K. D’Aquino, Kyle D. Copps, M. White
Diabetologia, 2009
Diabetologia, 2009
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Sadagurski, M., Norquay, L., Farhang, J., D’Aquino, K., Copps, K. D., & White, M. (2009). Human IL6 enhances leptin action in mice. Diabetologia.
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Sadagurski, M., L. Norquay, J. Farhang, K. D’Aquino, Kyle D. Copps, and M. White. “Human IL6 Enhances Leptin Action in Mice.” Diabetologia (2009).
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Sadagurski, M., et al. “Human IL6 Enhances Leptin Action in Mice.” Diabetologia, 2009.
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@article{m2009a,
title = {Human IL6 enhances leptin action in mice},
year = {2009},
journal = {Diabetologia},
author = {Sadagurski, M. and Norquay, L. and Farhang, J. and D’Aquino, K. and Copps, Kyle D. and White, M.}
}
Abstract
Aims/hypothesisInterleukin-6 is an inflammatory cytokine with pleiotropic effects upon nutrient homeostasis. Many reports show that circulating IL6 correlates with obesity and contributes to insulin resistance; however, IL6 can promote energy expenditure that improves glucose homeostasis.MethodsWe investigated nutrient homeostasis in C57BL/6J mice with sustained circulating human IL6 (hIL6) secreted predominantly from brain and lung (hIL6tg mice).ResultsThe hIL6tg mice displayed no features of systemic inflammation and were more insulin-sensitive than wild-type mice. On a high-fat diet, hIL6tg mice were lean, had low leptin concentrations, consumed less food and expended more energy than wild-type mice. Like ob/ob mice, the ob/obIL6 mice (generated by intercrossing ob/ob and hIL6tg mice) were obese and glucose-intolerant. However, low-dose leptin injections increased physical activity and reduced both body weight and food intake in ob/obIL6 mice, but was ineffective in ob/ob mice. Leptin increased hypothalamic signal transducer and activator of transcription-3 phosphorylation in ob/obIL6 mice, whereas ob/ob mice barely responded.Conclusions/interpretationHuman IL6 enhanced central leptin action in mice, promoting nutrient homeostasis and preventing diet-induced obesity.